反应详情

1.0 g (4.84 mmol, 1 equiv.) 1-Naphthalenecarboximidamide hydrochloride are suspended in 2 ml of DMSO and 0.29 g (5.81 mmol, 1.2 equiv.) hydrazine hydrate are added. After stirring at room temperature for 16 hours, 1.45 g (7.3 mmol, 1.5 equiv.) of the compound of Example 2A, dissolved in 10 ml of ethanol, are added. The reaction mixture is stirred at reflux for 1 hour and then at 60° C. (bath temperature) for 4 hours and then at room temperature over night. The mixture is evaporated to dryness in vacuo and the product is purified by flash chromatography.

1. additionare added
2. stirringThe reaction mixture is stirred
3. temperatureat reflux for 1 hour
4. waitat 60° C. (bath temperature) for 4 hours
5. waitat room temperature over night
6. customThe mixture is evaporated to dryness in vacuo
7. customthe product is purified by flash chromatography