4-Tert-butylcyclohexanecarbonyl chloride → 4-tert-butyl-N-[1-(3-tert-butyl-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)propyl]cyclohexanecarboxamide

HRID 1241495Notes

Reaction equation

HRID 1241495 reaction equation
[NH2:1][CH:2]([C:5]1[C:6](=[O:15])[NH:7][C:8]([C:11]([CH3:14])([CH3:13])[CH3:12])=[N:9][N:10]=1)[CH2:3][CH3:4].[C:16]([CH:20]1[CH2:25][CH2:24][CH:23]([C:26](Cl)=[O:27])[CH2:22][CH2:21]1)([CH3:19])([CH3:18])[CH3:17]>>[C:16]([CH:20]1[CH2:21][CH2:22][CH:23]([C:26]([NH:1][CH:2]([C:5]2[C:6](=[O:15])[NH:7][C:8]([C:11]([CH3:14])([CH3:13])[CH3:12])=[N:9][N:10]=2)[CH2:3][CH3:4])=[O:27])[CH2:24][CH2:25]1)([CH3:19])([CH3:17])[CH3:18]

Participants

3

Reactant 2

HCID 27572694-Tert-butylcyclohexanecarbonyl chlorideHCID 1355940906-(1-Aminopropyl)-3-tert-butyl-1,2,4-triazin-5(4h)-one

Product 1

HCID 1355940894-tert-butyl-N-[1-(3-tert-butyl-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)propyl]cyclohexanecarboxamide

Procedure

In analogy to the procedure for Example 36A, 210 mg (1.00 mmol) 6-(1-aminopropyl)-3-tert-butyl-1,2,4-triazin-5(4H)-one, 200 mg (1.00 mmol) 4-tert-butylcyclohexanecarbonyl chloride and proportionate amounts of the other reagents are used. The crude product is used in the next step without further purification.

Workup

  1. customThe crude product is used in the next step without further purification

Sources & evidence

ORD record
ord-7430f96f69964f2dae79215de9da8d9e
Source dataset
uspto-grants-2006_10
Patent number
US07115602B2

Reaction notes

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