Oxalyl chloride → HCID 178445652, compound

Participants

Reaction Steps

2.0 g (10.85 mmol) cis-4-tert-Butylcyclohexanecarboxylic acid (Example 42A) are dissolved in 50 ml dichloromethane, 1.65 g (13.02 mmol) ethanedioyl dichloride are added and the solution is stirred at room temperature for one hour. The mixture is then stirred at reflux for two hours and, after cooling down to room temperature, evaporated to dryness in vacuo. The residue is then dissolved in toluene two times and again evaporated to dryness in vacuo. The residue is used in the next step without further purification.

Provenance & Evidence