反应详情

2.0 g (10.85 mmol) cis-4-tert-Butylcyclohexanecarboxylic acid (Example 42A) are dissolved in 50 ml dichloromethane, 1.65 g (13.02 mmol) ethanedioyl dichloride are added and the solution is stirred at room temperature for one hour. The mixture is then stirred at reflux for two hours and, after cooling down to room temperature, evaporated to dryness in vacuo. The residue is then dissolved in toluene two times and again evaporated to dryness in vacuo. The residue is used in the next step without further purification.

1. stirringThe mixture is then stirred
2. temperatureat reflux for two hours
3. temperatureafter cooling down to room temperature
4. customevaporated to dryness in vacuo
5. dissolutionThe residue is then dissolved in toluene two times
6. customagain evaporated to dryness in vacuo
7. customThe residue is used in the next step without further purification