HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → HCID 135594097, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 4-tert-butyl-N-[1-(3-cyclopentyl-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)propyl]cyclohexanecarboxamide | HCID 135594108 | — |
| Product | HCID 135594097 | HCID 135594097 | — |
Reaction Steps
In analogy to the procedure for Example 1, 350 mg (0.90 mmol) crude 4-tert-butyl-N-[1-(3-cyclopentyl-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)propyl]cyclohexanecarboxamide, 140 mg (0.90 mmol) phosphoric trichloride are stirred at reflux for 3 hours, proportionate amounts of the solvents are used. The isomers are separated by chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07115602B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-c8fa56133fdf42fc921aa4bbae9ffa21 |
| Source note | uspto-grants-2006_10 |