Phosphorus oxychloride → HCID 135594097, compound

HRID 1241499Notes

Reaction equation

HRID 1241499 reaction equation
[C:1]([CH:5]1[CH2:10][CH2:9][CH:8]([C:11]([NH:13][CH:14]([C:17]2[C:18](=[O:28])[NH:19][C:20]([CH:23]3[CH2:27][CH2:26][CH2:25][CH2:24]3)=[N:21][N:22]=2)[CH2:15][CH3:16])=O)[CH2:7][CH2:6]1)([CH3:4])([CH3:3])[CH3:2].P(Cl)(Cl)(Cl)=O>>[C:1]([CH:5]1[CH2:10][CH2:9][CH:8]([C:11]2[N:22]3[C:17]([C:18](=[O:28])[NH:19][C:20]([CH:23]4[CH2:27][CH2:26][CH2:25][CH2:24]4)=[N:21]3)=[C:14]([CH2:15][CH3:16])[N:13]=2)[CH2:7][CH2:6]1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 1355941084-tert-butyl-N-[1-(3-cyclopentyl-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)propyl]cyclohexanecarboxamide

Product 1

HCID 135594097HCID 135594097, compound

Procedure

In analogy to the procedure for Example 1, 350 mg (0.90 mmol) crude 4-tert-butyl-N-[1-(3-cyclopentyl-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)propyl]cyclohexanecarboxamide, 140 mg (0.90 mmol) phosphoric trichloride are stirred at reflux for 3 hours, proportionate amounts of the solvents are used. The isomers are separated by chromatography.

Workup

  1. temperatureat reflux for 3 hours
  2. customThe isomers are separated by chromatography

Sources & evidence

ORD record
ord-c8fa56133fdf42fc921aa4bbae9ffa21
Source dataset
uspto-grants-2006_10
Patent number
US07115602B2

Reaction notes

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