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HRID1241534

反应详情

EQUATION

反应方程式

HRID 1241534 的结构方程式

REACTANTS

反应物

2
结构：CCOC(=O)/C=C(/C)N
HCID643756

未命名化合物

结构：O=C([O-])C(C(=O)[O-])(c1c(Cl)cc(Cl)cc1Cl)c1c(Cl)cc(Cl)cc1Cl
HCID21935290

未命名化合物

PRODUCTS

生成物

1
结构：CCOC(=O)c1c(O)cc(=O)[nH]c1C
HCID54688208

Ethyl 4-hydroxy-2-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate

C9H11NO4

AUXILIARIES

试剂、催化剂与溶剂

1
结构：COCCOCCOC
溶剂HCID8150

Diethylene glycol dimethyl ether

C6H14O3

PROCEDURE

实验过程

A solution of ethyl 3-aminocrotonate (12.6 g, 97.5 mmol) and of intermediate 11 in diglyme (400 ml) was heated at 100° C. for 3 hours during which the product separated out. After cooling, diethylether (1.5 l) was added and the desired intermediate 12 was filtered (14.2 g, 75%). m.p. 243–245° C.

WORKUP

后处理

  1. customseparated out
  2. temperatureAfter cooling
  3. additiondiethylether (1.5 l) was added
  4. filtrationthe desired intermediate 12 was filtered (14.2 g, 75%)