Ammonia methanol → HCID 54720309, compound

HRID 1241539Notes

Reaction equation

[CH2:1]([O:3][CH:4]([O:15][CH2:16][CH3:17])[C:5]1[O:10][C:9](=O)[CH:8]=[C:7]([OH:12])[C:6]=1[CH2:13][CH3:14])[CH3:2].CO.[NH3:20]>>[CH2:1]([O:3][CH:4]([O:15][CH2:16][CH3:17])[C:5]1[NH:20][C:9](=[O:10])[CH:8]=[C:7]([OH:12])[C:6]=1[CH2:13][CH3:14])[CH3:2]

Participants

Reactant 2

HCID 21705897Ammonia methanol

HCID 54720306HCID 54720306, compound

Product 1

HCID 54720309HCID 54720309, compoundYield 7.5%

Conditions

Temperature: 60 °C

Procedure

A mixture of intermediate 19 (20 g; 82 mmol) in CH3OH/NH3 (150 ml) was stirred at 60° C. for 4 hours, evaporated till dryness and taken up in diisopropyl ether. The precipitate was filtered to yield 1.5 g of intermediate 20 (7.5%). The product was used without further purification in the next reaction step.

Workup

customevaporated till dryness
filtrationThe precipitate was filtered

Sources & evidence

ORD record: ord-c9f8ea7d31ae4c848fed09e724a76ca0
Source dataset: uspto-grants-2006_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07115608B2

Reaction notes

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