Water → HCID 10023837, compound

HRID 1241540Notes

Reaction equation

HRID 1241540 reaction equation
[BH4-].[Na+].[CH3:3][C:4]1[CH:5]=[C:6]([CH:20]=[C:21]([CH3:23])[CH:22]=1)[O:7][C:8]1[C:9]([CH2:18][CH3:19])=[C:10]([CH:16]=[O:17])[NH:11][C:12](=[O:15])[C:13]=1[I:14].O>CO>[CH3:23][C:21]1[CH:20]=[C:6]([CH:5]=[C:4]([CH3:3])[CH:22]=1)[O:7][C:8]1[C:9]([CH2:18][CH3:19])=[C:10]([CH2:16][OH:17])[NH:11][C:12](=[O:15])[C:13]=1[I:14]

Participants

5

Reactant 3

HCID 962WaterHCID 4311764Sodium borohydrideHCID 21935301HCID 21935301, compound

Product 1

HCID 10023837HCID 10023837, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

NaBH4 (0.047 g; 1.3 mmol) was added to a mixture of compound 159 (0.5 g; 0.013 mol) in methanol (3 ml). The mixture was stirred at room temperature for 1 hour. Water was added. The precipitate was filtered off, taken up in diisopropyl ether and dried to yield 0.26 g (52%), m.p.=70° C.).

Workup

  1. filtrationThe precipitate was filtered off
  2. customdried
  3. customto yield 0.26 g (52%), m.p.=70° C.)

Sources & evidence

ORD record
ord-ef09482df842418ca62e8f31c693545b
Source dataset
uspto-grants-2006_10
Patent number
US07115608B2

Reaction notes

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