1,3-Benzodioxol-4-amine → HCID 21936009, compound

HRID 1241573Notes

Reaction equation

HRID 1241573 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:17][CH2:18][CH2:19][O:20][CH3:21])=[C:9]([O:12][CH2:13][CH2:14][O:15][CH3:16])[CH:10]=2)[N:5]=[CH:4][N:3]=1.[CH2:22]1[O:31][C:30]2[C:24](=[C:25]([CH:27]=[CH:28][CH:29]=2)[NH2:26])[O:23]1>>[ClH:1].[CH3:16][O:15][CH2:14][CH2:13][O:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][C:8]=1[O:17][CH2:18][CH2:19][O:20][CH3:21])[N:5]=[CH:4][N:3]=[C:2]2[NH:26][C:25]1[CH:27]=[CH:28][CH:29]=[C:30]2[O:31][CH2:22][O:23][C:24]=12

Participants

3

Reactant 2

HCID 103131651,3-Benzodioxol-4-amineHCID 112899424-Chloro-6,7-bis(2-methoxyethoxy)quinazoline

Product 1

HCID 21936009HCID 21936009, compound

Procedure

Using an analogous procedure to that described in Example 1, 4-chloro-6,7-di-(2-methoxyethoxy)quinazoline (U.S. Pat. No. 5,747,498; 0.1 g) was reacted with 2,3-methylenedioxyaniline (0.048 g) to give the title compound (0.121 g); NMR Spectrum: (DMSOd6 and CF3CO2D) 3.5 (s, 6H), 3.8 (m, 4H), 4.35 (m, 4H), 6.05 (s, 2H), 6.95 (m, 3H), 7.4 (s, 1H), 8.2 (s, 1H), 8.85 (s, 1H); Mass Spectrum: M+H+ 414.

Sources & evidence

ORD record
ord-be14a9143b874b6b9bcaec809f0c60db
Source dataset
uspto-grants-2006_10
Patent number
US07115615B2

Reaction notes

Loading…