Tert-Butylamine → HCID 21936581, compound

Participants

Reaction Steps

To a solution of 4-cyanophenyl isothiocyanate (1.00 g, 6.24 mmol) in THF (25 mL) at room temperature was added a solution of tert-butylamine (1.31 mL, 12.5 mmol) and the reaction was stirred at room temperature for 6 hours. The mixture was concentrated in vacuo and the resulting residue was triturated with diethyl ether and filtered to afford 1.37 g (94%) of 1-(4-cyanophenyl)-3-(tert-butyl)-thiourea as a white solid which was used without further purification.

Provenance & Evidence