Tert-Butylamine → HCID 21936581, compound

HRID 1241611Notes

Reaction equation

HRID 1241611 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]=[C:10]=[S:11])=[CH:5][CH:4]=1)#[N:2].[C:12]([NH2:16])([CH3:15])([CH3:14])[CH3:13]>C1COCC1>[C:1]([C:3]1[CH:4]=[CH:5][C:6]([NH:9][C:10]([NH:16][C:12]([CH3:15])([CH3:14])[CH3:13])=[S:11])=[CH:7][CH:8]=1)#[N:2]

Participants

4

Reactant 2

HCID 6385Tert-ButylamineHCID 17626Benzonitrile, 4-isothiocyanato-

Product 1

HCID 21936581HCID 21936581, compoundYield 94.1%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 4-cyanophenyl isothiocyanate (1.00 g, 6.24 mmol) in THF (25 mL) at room temperature was added a solution of tert-butylamine (1.31 mL, 12.5 mmol) and the reaction was stirred at room temperature for 6 hours. The mixture was concentrated in vacuo and the resulting residue was triturated with diethyl ether and filtered to afford 1.37 g (94%) of 1-(4-cyanophenyl)-3-(tert-butyl)-thiourea as a white solid which was used without further purification.

Workup

  1. concentrationThe mixture was concentrated in vacuo
  2. customthe resulting residue was triturated with diethyl ether
  3. filtrationfiltered

Sources & evidence

ORD record
ord-0dc1629f401f454787688c27e36cb223
Source dataset
uspto-grants-2006_10
Patent number
US07115620B2

Reaction notes

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