Aluminum(III) Chloride → HCID 178479874, compound

HRID 1241698Notes

Reaction equation

HRID 1241698 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]2=[N:8][C:9]3[C:22]4[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=4[N:16]([CH3:23])[C:15]4[C:10]=3[C:11]([CH:12]=[C:13]([O:24]C)[CH:14]=4)=[C:4]2[CH:3]=1.ClC1C=CC2=NC3C4C=CC=CC=4NC4C=3C(C=C(OC)C=4)=C2C=1.[Cl-].[Al+3].[Cl-].[Cl-]>C1C=CC=CC=1>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]2=[N:8][C:9]3[C:22]4[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=4[N:16]([CH3:23])[C:15]4[C:10]=3[C:11]([CH:12]=[C:13]([OH:24])[CH:14]=4)=[C:4]2[CH:3]=1

Participants

5

Reactant 3

HCID 6451240Aluminum(III) ChlorideHCID 11035407HCID 11035407, compoundHCID 21936568HCID 21936568, compound

Product 1

HCID 178479874HCID 178479874, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

The general procedure (Method K) applied to 3-chloro-6-methoxy-8-methyl-8H-quino[4,3,2-kl]acridine, 32 (5.5 g, 15.9 mmol), with aluminium chloride (6.3 g, 3 eq), and benzene (500 ml) gave the title compound as a yellow solid (4.5 g, 13.5 mmol, 88%).

Sources & evidence

ORD record
ord-8bca587a434546eb957ad5ba8163dcb2
Source dataset
uspto-grants-2006_10
Patent number
US07115619B2

Reaction notes

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