Methyl Acrylate → HCID 11132296, compound

HRID 1241702Notes

Reaction equation

HRID 1241702 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]2=[N:8][C:9]3[C:22]4[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=4[N:16]([CH3:23])[C:15]4[C:10]=3[C:11]([CH:12]=[CH:13][CH:14]=4)=[C:4]2[CH:3]=1.[C:24]([O:28][CH3:29])(=[O:27])[CH:25]=[CH2:26]>>[CH3:29][O:28][C:24](=[O:27])/[CH:25]=[CH:26]/[C:2]1[CH:7]=[CH:6][C:5]2=[N:8][C:9]3[C:22]4[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=4[N:16]([CH3:23])[C:15]4[C:10]=3[C:11]([CH:12]=[CH:13][CH:14]=4)=[C:4]2[CH:3]=1

Participants

3

Reactant 2

HCID 7294Methyl AcrylateHCID 10925151HCID 10925151, compound2×

Product 1

HCID 11132296HCID 11132296, compoundYield 66%

Procedure

The general procedure (Method M, described below) applied to 3-chloro-8-methyl-8H-quino[4,3,2-kl]acridine, 28 (160 mg, 0.5 mmol) and methyl acrylate (0.064 mL, 1.5 eq) gave the title compound (120 mg, 0.33 mmol, 66%).

Sources & evidence

ORD record
ord-fb5a66ec4c5948ec9ef9c0579f1cd613
Source dataset
uspto-grants-2006_10
Patent number
US07115619B2

Reaction notes

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