Hydrogen chloride-ethyl acetate → HCID 21937043, compound

HRID 1241908Notes

Reaction equation

HRID 1241908 reaction equation
C(OC([NH:8][CH2:9][CH2:10][NH:11][C:12]1[CH:13]=[C:14]([C:18]2[N:19]=[C:20]([S:23][CH2:24][C:25]([NH:27][CH:28]3[CH2:33][CH2:32][N:31]([CH2:34][C:35]4[CH:40]=[CH:39][C:38]([Cl:41])=[C:37]([Cl:42])[CH:36]=4)[CH2:30][CH2:29]3)=[O:26])[S:21][CH:22]=2)[CH:15]=[CH:16][CH:17]=1)=O)(C)(C)C.C(OCC)(=O)C.[ClH:49]>C(OCC)(=O)C>[ClH:41].[ClH:49].[NH2:8][CH2:9][CH2:10][NH:11][C:12]1[CH:13]=[C:14]([C:18]2[N:19]=[C:20]([S:23][CH2:24][C:25]([NH:27][CH:28]3[CH2:33][CH2:32][N:31]([CH2:34][C:35]4[CH:40]=[CH:39][C:38]([Cl:41])=[C:37]([Cl:42])[CH:36]=4)[CH2:30][CH2:29]3)=[O:26])[S:21][CH:22]=2)[CH:15]=[CH:16][CH:17]=1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 21937199HCID 21937199, compound

Product 1

HCID 21937043HCID 21937043, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The product (238 mg) of Example 154 was dissolved in ethyl acetate (1 mL), and a 4 mol/L hydrogen chloride-ethyl acetate solution (0.55 mL) was added to the solution under ice-cooling. The mixture was stirred at room temperature for 20 hrs, and the resulting solids were collected by filtration to give the title compound (201 mg) as a white powder.

Workup

  1. temperaturecooling
  2. filtrationthe resulting solids were collected by filtration

Sources & evidence

ORD record
ord-19193c18c944428cbf64813c7bff1906
Source dataset
uspto-grants-2006_10
Patent number
US07115635B2

Reaction notes

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