1,1'-Carbonyldiimidazole → 1-Cyclohexylmethyl-6-(4-methyl-piperazin-1-yl)-5-phenylamino-1,3-dihydro-benzoimidazol-2-one

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Reaction Steps

A solution of N1-cyclohexylmethyl-5-(4-methyl-piperazin-1-yl)-N4-phenyl-benzene-1,2,4-triamine (0.10 g, 0.25 mmol) and 1,1′-carbonyldiimidazole (0.12 g, 0.76 mmol) in THF (3 mL) was stirred at room temperature for 17.5 h. The solvent was evaporated and the resulting residue was chromatographed (FCC, 5% MeOH/CH2Cl2) to give the title compound as a white solid (0.07 g, 61.6% yield). M+, 420.

Provenance & Evidence