Oxalyl chloride → 5-(4'-Acetamido-2'-methylbiphenyl-4-carbonyl)-1'-methyl-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine]

HRID 124196Notes

Reaction equation

HRID 124196 reaction equation
[C:1]([CH3:2])(=[O:3])[NH:4][c:5]1[cH:6][c:7]([CH3:20])[c:8](-[c:11]2[cH:12][cH:13][c:14]([C:17](=[O:18])[OH:19])[cH:15][cH:16]2)[cH:9][cH:10]1.[CH3:21][N:22]1[CH2:23][CH2:24][C:25]2([CH2:26][O:27][c:28]3[cH:29][c:30]4[c:34]([cH:35][c:36]32)[NH:33][CH2:32][CH2:31]4)[CH2:37][CH2:38]1.[Cl:39][C:40]([C:41]([Cl:42])=[O:43])=[O:44]>>[C:1]([CH3:2])(=[O:3])[NH:4][c:5]1[cH:6][c:7]([CH3:20])[c:8](-[c:11]2[cH:12][cH:13][c:14]([C:17](=[O:19])[N:33]3[CH2:32][CH2:31][c:30]4[cH:29][c:28]5[c:36]([cH:35][c:34]43)[C:25]3([CH2:24][CH2:23][N:22]([CH3:21])[CH2:38][CH2:37]3)[CH2:26][O:27]5)[cH:15][cH:16]2)[cH:9][cH:10]1

Participants

4

Reactant 3

HCID 65578Oxalyl chlorideHCID 106579521'-Methyl-6,7-dihydro-2H,5H-spiro[furo[2,3-f]indole-3,4'-piperidine]HCID 186942634'-Acetamido-2'-methylbiphenyl-4-carboxylic acid

Product 1

HCID 186943005-(4'-Acetamido-2'-methylbiphenyl-4-carbonyl)-1'-methyl-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine]

Sources & evidence

ORD record
ord-b8f0ffd0868d42d7aca2983353acca92
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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