Methyl iodide → HCID 10156118, compound

HRID 1242158Notes

Reaction equation

HRID 1242158 reaction equation
[C:1]1([N:7]2[C:11]3[CH:12]=[C:13]([O:16][CH2:17][CH2:18][C:19]([OH:21])=[O:20])[CH:14]=[CH:15][C:10]=3[N:9]=[C:8]2[C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:28](=O)([O-])[O-].[Cs+].[Cs+].CI>CN(C)C=O.ClCCl>[CH3:28][O:20][C:19](=[O:21])[CH2:18][CH2:17][O:16][C:13]1[CH:14]=[CH:15][C:10]2[N:9]=[C:8]([C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=3)[N:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[C:11]=2[CH:12]=1

Participants

6

Reactant 3

HCID 6328Methyl iodideHCID 10796Cesium carbonateHCID 21937930HCID 21937930, compound

Product 1

HCID 10156118HCID 10156118, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 6344DichloromethaneSolvent

Procedure

45 mg of 3-[(1,2-diphenyl-1H-benzimidazol-6-yl)oxy]propanoic acid was dissolved in 0.5 ml of N,N-dimethylformamide and mixed with 41 mg of cesium carbonate and 10 μl of methyl iodide. It was allowed to stir for 2 days, diluted with dichloromethane, filtered, the filtrate was concentrated by evaporation in a vacuum, and the residue was chromatographed on silica gel.

Workup

  1. filtrationfiltered
  2. concentrationthe filtrate was concentrated by evaporation in a vacuum
  3. customthe residue was chromatographed on silica gel

Sources & evidence

ORD record
ord-6f982959331e42a5b204d5f3751a8132
Source dataset
uspto-grants-2006_10
Patent number
US07115645B2

Reaction notes

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