3-Aminobenzonitrile → HCID 21938063, compound

HRID 1242164Notes

Reaction equation

HRID 1242164 reaction equation
F[C:2]1[CH:3]=[C:4]([O:11][CH3:12])[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9].[NH2:13][C:14]1[CH:15]=[C:16]([CH:19]=[CH:20][CH:21]=1)[C:17]#[N:18]>C(OCC)(=O)C>[CH3:12][O:11][C:4]1[CH:5]=[CH:6][C:7]([N+:8]([O-:10])=[O:9])=[C:2]([NH:13][C:14]2[CH:15]=[C:16]([CH:19]=[CH:20][CH:21]=2)[C:17]#[N:18])[CH:3]=1

Participants

4

Reactant 2

HCID 167023-AminobenzonitrileHCID 5656543-Fluoro-4-nitroanisole

Product 1

HCID 21938063HCID 21938063, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

2 g of 3-fluoro-4-nitroanisole and 15 ml of 3-aminobenzonitrile were stirred for 65 hours at 140° C. The batch was then diluted with ethyl acetate, washed three times with water and once with saturated sodium chloride solution, dried on sodium sulfate, concentrated by evaporation in a vacuum, and the residue was chromatographed on silica gel.

Workup

  1. washwashed three times with water
  2. dry with materialonce with saturated sodium chloride solution, dried on sodium sulfate
  3. concentrationconcentrated by evaporation in a vacuum
  4. customthe residue was chromatographed on silica gel

Sources & evidence

ORD record
ord-743a3143ca884530ab8946b5d6a85210
Source dataset
uspto-grants-2006_10
Patent number
US07115645B2

Reaction notes

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