HCID 21938126, compound → HCID 21937959, compound

HRID 1242196Notes

Reaction equation

HRID 1242196 reaction equation
C([O:5][C:6](=[O:34])[CH2:7][CH2:8][O:9][CH2:10][CH2:11][O:12][C:13]1[CH:14]=[CH:15][C:16]2[N:20]=[C:19]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[N:18]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)[C:17]=2[CH:33]=1)(C)(C)C>FC(F)(F)C(O)=O.O>[C:27]1([N:18]2[C:17]3[CH:33]=[C:13]([O:12][CH2:11][CH2:10][O:9][CH2:8][CH2:7][C:6]([OH:34])=[O:5])[CH:14]=[CH:15][C:16]=3[N:20]=[C:19]2[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1

Participants

4

Reactant 1

HCID 21938126HCID 21938126, compound

Product 1

HCID 21937959HCID 21937959, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

50 mg of 3-[2-[(1,2-diphenyl-1H-benzimidazol-6-yl)oxy]ethoxy]propanoic acid-tert-butyl ester was dissolved in 0.5 ml of trifluoroacetic acid and stirred for 15 hours. Then, it was diluted with water and extracted three times with ethyl acetate. The combined organic phases were washed with saturated sodium chloride solution, dried on sodium sulfate and concentrated by evaporation in a vacuum. The residue was chromatographed on silica gel.

Workup

  1. extractionextracted three times with ethyl acetate
  2. washThe combined organic phases were washed with saturated sodium chloride solution
  3. customdried on sodium sulfate
  4. concentrationconcentrated by evaporation in a vacuum
  5. customThe residue was chromatographed on silica gel

Sources & evidence

ORD record
ord-27365a4569f745be8f69baecb11adde1
Source dataset
uspto-grants-2006_10
Patent number
US07115645B2

Reaction notes

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