Hydrogen Bromide → HCID 21938168, compound

HRID 1242203Notes

Reaction equation

HRID 1242203 reaction equation
[Br:1][C:2]1[C:10]2[N:9]=[C:8]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[N:7]([C:17]3[CH:22]=[CH:21][C:20]([CH3:23])=[CH:19][CH:18]=3)[C:6]=2[CH:5]=[C:4]([O:24]C)[CH:3]=1.Br>C(O)(=O)C>[Br:1][C:2]1[C:10]2[N:9]=[C:8]([C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:7]([C:17]3[CH:22]=[CH:21][C:20]([CH3:23])=[CH:19][CH:18]=3)[C:6]=2[CH:5]=[C:4]([OH:24])[CH:3]=1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 21938149HCID 21938149, compound

Product 1

HCID 21938168HCID 21938168, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

1.2 g of 4-bromo-6-methoxy-1-(4-methylphenyl)-2-phenyl-1H-benzimidazole, 6 ml of acetic acid and 6 ml of aqueous hydrobromic acid (62%) are boiled for 5.5 hours. Then, it is precipitated with waters and the precipitate is suctioned off. The latter was then dispersed between ethyl acetate and 2N sodium hydroxide solution. After the organic phase was washed with water, it was concentrated by evaporation.

Workup

  1. customThen, it is precipitated with waters
  2. additionThe latter was then dispersed between ethyl acetate and 2N sodium hydroxide solution
  3. washAfter the organic phase was washed with water, it
  4. concentrationwas concentrated by evaporation

Sources & evidence

ORD record
ord-ce2c3746bb6c408ea102f5fb7d3cebe3
Source dataset
uspto-grants-2006_10
Patent number
US07115645B2

Reaction notes

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