反应详情

0.600 g (2.26 mmol) of the above prepared 2-methyl-6-(3-trifluoromethyl-phenyl)-pyridine-3-carbaldehyde (example 3A]) was dissolved in 11.3 ml of abs. THF and treated at −78° C. with 1.2 ml of 2M propyl magnesium chloride solution (in EtOEt, 1.06 eq.). After stirring for 15 Min. at 0° C., the reaction mixture was carefully poured onto crashed ice/NH4Cl, extracted twice with AcOEt, washed with water, dried over sodium sulfate, and evaporated to dryness. Flash chromatography (SiO2, hexane/AcOEt=8/2) yielded then 0.281 g of the title compound as white crystals of mp. 83–85° C.

1. dissolutionwas dissolved in 11.3 ml of abs
2. additionat 0° C., the reaction mixture was carefully poured
3. extractionextracted twice with AcOEt
4. washwashed with water
5. dry with materialdried over sodium sulfate
6. customevaporated to dryness
7. customFlash chromatography (SiO2, hexane/AcOEt=8/2) yielded