反应详情

温度

100 °C

A mixture of 25 g (90 mmol) of the above prepared [2-methyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-yl]-acetonitrile, 20 g of sodium hydroxide (500 mmol), 60 ml of water and 250 ml of propanol was stirred vigorously at 100° C. Hydrolysis was complete after 2 hours. The reaction mixture was then evaporated to dryness and the residue was dissolved in 70 ml of water; then, 60 ml of cold 8 N aqueous HCl was added and the compound was extracted with three portions of 250 ml of ethyl acetate; the combined organic phases were washed with water and brine, dried over anhydrous sodium sulfate and evaporated to dryness to yield 25.1 g of the title product as pale yellow solid.

1. additionA mixture of 25 g (90 mmol) of the
2. customHydrolysis
3. customThe reaction mixture was then evaporated to dryness
4. dissolutionthe residue was dissolved in 70 ml of water
5. additionthen, 60 ml of cold 8 N aqueous HCl was added
6. extractionthe compound was extracted with three portions of 250 ml of ethyl acetate
7. washthe combined organic phases were washed with water and brine
8. dry with materialdried over anhydrous sodium sulfate
9. customevaporated to dryness