反应详情

13.8 g (43 mmol) of 2-methyl-2-(3-nitro-5-trifluoromethyl-phenoxy)-propionic acid ethyl ester was dissolved in 300 ml of ethanol and hydrogenated with 1.14 g of Pd—C (10%), 1 bar H2, 25° C., for two hours. The reaction mixture was then filtered (Celite), the filter cake was washed twice with ethanol and the filtrate was evaporated. The crude product was purified by flash chromatography (SiO2, heptane/EtOAc) which gave 11.0 g of the title compound as yellow oil.

1. filtrationThe reaction mixture was then filtered (Celite)
2. washthe filter cake was washed twice with ethanol
3. customthe filtrate was evaporated
4. customThe crude product was purified by flash chromatography (SiO2, heptane/EtOAc) which