HCID 67072313, compound → 2-(3-Amino-5-trifluoromethyl-phenoxy)-2-methyl-propionic acid ethyl ester

Participants

Reaction Steps

13.8 g (43 mmol) of 2-methyl-2-(3-nitro-5-trifluoromethyl-phenoxy)-propionic acid ethyl ester was dissolved in 300 ml of ethanol and hydrogenated with 1.14 g of Pd—C (10%), 1 bar H2, 25° C., for two hours. The reaction mixture was then filtered (Celite), the filter cake was washed twice with ethanol and the filtrate was evaporated. The crude product was purified by flash chromatography (SiO2, heptane/EtOAc) which gave 11.0 g of the title compound as yellow oil.

Provenance & Evidence