HRID1242416

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COCCc1nc(-c2ccc(C(F)(F)F)cc2)nc(C)c1CCl

HCID21935749

未命名化合物

HCID67072284

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)C(C)(C)Oc1cccc(C(=O)N(C)Cc2c(C)nc(-c3ccc(C(F)(F)F)cc3)nc2CCOC)c1

HCID67072260

未命名化合物

PROCEDURE

实验过程

In analogy to the procedures described in examples 59C] and 26C], 2-methyl-2-(3-methylcarbamoyl-phenoxy)-propionic acid ethyl ester (example 59B]) was reacted 5-chloromethyl-4-(2-methoxy-ethyl)-6-methyl-2-(4-trifluoromethyl-phenyl)-pyrimidine (example 118G]) to give 2-(3-{[4-(2-methoxy-ethyl)-6-methyl-2-(4-trifluoromethyl-phenyl)-pyrimidin-5-ylmethyl]-methyl-carbamoyl}-phenoxy)-2-methyl-propionic acid ethyl ester, which was subsequently saponified to yield the title compound as light brown solid.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5200ec95713c41f4aaadb03d0f5b8567
来源数据集: uspto-grants-2006_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07115611B2
来源说明: uspto-grants-2006_10

反应 SMILES

[CH2:1]([O:3][C:4](=[O:19])[C:5]([CH3:18])([O:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([C:14](=[O:17])[NH:15][CH3:16])[CH:9]=1)[CH3:6])[CH3:2].Cl[CH2:21][C:22]1[C:23]([CH2:39][CH2:40][O:41][CH3:42])=[N:24][C:25]([C:29]2[CH:34]=[CH:33][C:32]([C:35]([F:38])([F:37])[F:36])=[CH:31][CH:30]=2)=[N:26][C:27]=1[CH3:28]>>[CH2:1]([O:3][C:4](=[O:19])[C:5]([O:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([C:14](=[O:17])[N:15]([CH2:21][C:22]2[C:23]([CH2:39][CH2:40][O:41][CH3:42])=[N:24][C:25]([C:29]3[CH:30]=[CH:31][C:32]([C:35]([F:38])([F:36])[F:37])=[CH:33][CH:34]=3)=[N:26][C:27]=2[CH3:28])[CH3:16])[CH:9]=1)([CH3:18])[CH3:6])[CH3:2]