HCID 21638546, compound → HCID 67072407, compound

HRID 1242424Notes

Reaction equation

HRID 1242424 reaction equation
[CH2:1]([O:3][C:4](=[O:16])[CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][C:8]=1[O:14][CH3:15])[CH3:2].Cl[CH2:18][C:19]1[C:20]([CH3:35])=[N:21][C:22]([C:25]2[CH:30]=[CH:29][C:28]([C:31]([F:34])([F:33])[F:32])=[CH:27][CH:26]=2)=[CH:23][CH:24]=1>>[CH2:1]([O:3][C:4](=[O:16])[CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:18][C:19]2[C:20]([CH3:35])=[N:21][C:22]([C:25]3[CH:26]=[CH:27][C:28]([C:31]([F:34])([F:32])[F:33])=[CH:29][CH:30]=3)=[CH:23][CH:24]=2)=[CH:9][C:8]=1[O:14][CH3:15])[CH3:2]

Participants

3

Reactant 2

HCID 21638546HCID 21638546, compoundHCID 219357513-Chloromethyl-2-methyl-6-(4-trifluoromethyl-phenyl)-pyridine

Product 1

HCID 67072407HCID 67072407, compound

Procedure

In analogy to the procedures described in examples 8A] and 31B], 3-(4-hydroxy-2-methoxy-phenyl)-propionic acid ethyl ester was reacted with 3-chloromethyl-2-methyl-6-(4-trifluoromethyl-phenyl)-pyridine (example 1N]) to give 3-{2-methoxy-4-[2-methyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-ylmethoxy]-phenyl}-propionic acid ethyl ester, which was subsequently saponified to yield the title compound as colorless solid.

Sources & evidence

ORD record
ord-cb7d524260ae4afbaab957cc3a145290
Source dataset
uspto-grants-2006_10
Patent number
US07115611B2

Reaction notes

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