4-(Trifluoromethoxy)phenylboronic acid → 2-(4-Trifluoromethoxy-phenyl)-4-trifluoromethyl-pyrimidine-5-carboxylic acid ethyl ester

HRID 1242446Notes

Reaction equation

HRID 1242446 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[C:5]([C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:4][N:3]=1.[F:17][C:18]([F:30])([F:29])[O:19][C:20]1[CH:25]=[CH:24][C:23](B(O)O)=[CH:22][CH:21]=1>>[CH2:15]([O:14][C:12]([C:5]1[C:6]([C:8]([F:11])([F:10])[F:9])=[N:7][C:2]([C:23]2[CH:22]=[CH:21][C:20]([O:19][C:18]([F:17])([F:29])[F:30])=[CH:25][CH:24]=2)=[N:3][CH:4]=1)=[O:13])[CH3:16]

Participants

3

Reactant 2

HCID 27343864-(Trifluoromethoxy)phenylboronic acidHCID 2780355Ethyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate

Product 1

HCID 865978132-(4-Trifluoromethoxy-phenyl)-4-trifluoromethyl-pyrimidine-5-carboxylic acid ethyl ester

Procedure

In analogy to the procedures described in examples 108B], ethyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate and 4-(trifluoromethoxy)phenylboronic acid gave the title compound as an off-white powder.

Sources & evidence

ORD record
ord-fe71bcd8042541afb8e9221f979459b2
Source dataset
uspto-grants-2006_10
Patent number
US07115611B2

Reaction notes

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