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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1242446Generated: October 30, 2026

4-(Trifluoromethoxy)phenylboronic acid → 2-(4-Trifluoromethoxy-phenyl)-4-trifluoromethyl-pyrimidine-5-carboxylic acid ethyl ester

https://huagongshe.com/reaction/1242446

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Trifluoromethoxy)phenylboronic acidHCID 2734386—
ReactantEthyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylateHCID 2780355—
Product2-(4-Trifluoromethoxy-phenyl)-4-trifluoromethyl-pyrimidine-5-carboxylic acid ethyl esterHCID 86597813—

Reaction Steps

In analogy to the procedures described in examples 108B], ethyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate and 4-(trifluoromethoxy)phenylboronic acid gave the title compound as an off-white powder.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07115611B2
Source datasetuspto-grants-2006_10
ORD IDord-fe71bcd8042541afb8e9221f979459b2
Source noteuspto-grants-2006_10