Trifluoroacetic acid → 2-Methyl-6-(4-(trifluoromethyl)phenyl)pyridin-3-amine

HRID 1242482Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1242482
C(OC(=O)[NH:7][C:8]1[C:9]([CH3:24])=[N:10][C:11]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][CH:15]=2)=[CH:12][CH:13]=1)(C)(C)C.FC(F)(F)C(O)=O>>[CH3:24][C:9]1[C:8]([NH2:7])=[CH:13][CH:12]=[C:11]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:22])([F:21])[F:23])=[CH:16][CH:15]=2)[N:10]=1

Komponenten

3

Edukt 2

HCID 6422Trifluoroacetic acidHCID 67072248[2-Methyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-yl]-carbamic acid tert-butyl ester

Produkt 1

HCID 219358322-Methyl-6-(4-(trifluoromethyl)phenyl)pyridin-3-amine

Versuchsvorschrift

In analog to the procedure described in example 5F], [2-methyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-yl]-carbamic acid tert-butyl ester was reacted with trifluoroacetic acid to yield the title compound as colorless solid.

Quellen und Nachweise

ORD-Eintrag
ord-c97905334bb04f2d99b71115f9ac5d73
Quelldatensatz
uspto-grants-2006_10
Patentnummer
US07115611B2

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