Trifluoroacetic acid → HCID 21935906, compound

HRID 1242498Notes

Reaction equation

C([O:5][C:6](=[O:41])[C:7]([CH3:40])([O:9][C:10]1[CH:15]=[CH:14][C:13]([CH2:16][C:17](=[O:39])[NH:18][C:19]2[CH:20]=[N:21][C:22]([C:29]3[CH:34]=[CH:33][C:32]([C:35]([F:38])([F:37])[F:36])=[CH:31][CH:30]=3)=[CH:23][C:24]=2[C:25]([F:28])([F:27])[F:26])=[CH:12][CH:11]=1)[CH3:8])(C)(C)C.FC(F)(F)C(O)=O>>[CH3:40][C:7]([O:9][C:10]1[CH:15]=[CH:14][C:13]([CH2:16][C:17](=[O:39])[NH:18][C:19]2[CH:20]=[N:21][C:22]([C:29]3[CH:30]=[CH:31][C:32]([C:35]([F:37])([F:38])[F:36])=[CH:33][CH:34]=3)=[CH:23][C:24]=2[C:25]([F:26])([F:27])[F:28])=[CH:12][CH:11]=1)([CH3:8])[C:6]([OH:41])=[O:5]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 86597819HCID 86597819, compound

Product 1

HCID 21935906HCID 21935906, compound

Procedure

In analogy to the procedure described in example 124C], 2-methyl-2-(4-{[4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-ylcarbamoyl]-methyl}-phenoxy)-propionic acid tert-butyl ester was cleaved with trifluoroacetic acid to yield the title compound as light yellow oil.

Sources & evidence

ORD record: ord-c1e46b1e7a7946d2bb80ace71a58c561
Source dataset: uspto-grants-2006_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07115611B2

Reaction notes

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