3-Chloromethyl-2-cyclopropyl-6-(4-trifluoromethoxy-phenyl)-pyridine → 2-{4-[2-Cyclopropyl-6-(4-trifluoromethoxy-phenyl)-pyridin-3-ylmethylsulfanyl]-2-methyl-phenoxy}-2-methyl-propionic acid ethyl ester

HRID 1242507Notes

Reaction equation

HRID 1242507 reaction equation
[CH2:1]([O:3][C:4](=[O:20])[C:5]([O:8][C:9]1[CH:14]=[CH:13][C:12]([S:15][C:16](=O)[CH3:17])=[CH:11][C:10]=1[CH3:19])([CH3:7])[CH3:6])[CH3:2].ClCC1[C:24]([CH:40]2[CH2:42][CH2:41]2)=[N:25][C:26]([C:29]2[CH:34]=[CH:33][C:32]([O:35][C:36]([F:39])([F:38])[F:37])=[CH:31][CH:30]=2)=[CH:27][CH:28]=1>>[CH2:1]([O:3][C:4](=[O:20])[C:5]([O:8][C:9]1[CH:14]=[CH:13][C:12]([S:15][CH2:16][C:17]2[C:24]([CH:40]3[CH2:41][CH2:42]3)=[N:25][C:26]([C:29]3[CH:34]=[CH:33][C:32]([O:35][C:36]([F:37])([F:39])[F:38])=[CH:31][CH:30]=3)=[CH:27][CH:28]=2)=[CH:11][C:10]=1[CH3:19])([CH3:7])[CH3:6])[CH3:2]

Participants

3

Reactant 2

HCID 219356543-Chloromethyl-2-cyclopropyl-6-(4-trifluoromethoxy-phenyl)-pyridineHCID 865978202-(4-Acetylsulfanyl-2-methyl-phenoxy)-2-methyl-propionic acid ethyl ester

Product 1

HCID 670723082-{4-[2-Cyclopropyl-6-(4-trifluoromethoxy-phenyl)-pyridin-3-ylmethylsulfanyl]-2-methyl-phenoxy}-2-methyl-propionic acid ethyl ester

Procedure

In analogy to the procedure described in example 142D], 2-(4-acetylsulfanyl-2-methyl-phenoxy)-2-methyl-propionic acid ethyl ester (example 142C]) was reacted with 3-chloromethyl-2-cyclopropyl-6-(4-trifluoromethoxy-phenyl)-pyridine (example 143F]) to give the title compound as colorless oil.

Sources & evidence

ORD record
ord-fc52a2398d61453eb9ef62799a22272c
Source dataset
uspto-grants-2006_10
Patent number
US07115611B2

Reaction notes

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