HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloromethyl-2-cyclopropyl-6-(4-trifluoromethoxy-phenyl)-pyridine → 2-{4-[2-Cyclopropyl-6-(4-trifluoromethoxy-phenyl)-pyridin-3-ylmethylsulfanyl]-2-methyl-phenoxy}-2-methyl-propionic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloromethyl-2-cyclopropyl-6-(4-trifluoromethoxy-phenyl)-pyridine | HCID 21935654 | — |
| Reactant | 2-(4-Acetylsulfanyl-2-methyl-phenoxy)-2-methyl-propionic acid ethyl ester | HCID 86597820 | — |
| Product | 2-{4-[2-Cyclopropyl-6-(4-trifluoromethoxy-phenyl)-pyridin-3-ylmethylsulfanyl]-2-methyl-phenoxy}-2-methyl-propionic acid ethyl ester | HCID 67072308 | — |
Reaction Steps
In analogy to the procedure described in example 142D], 2-(4-acetylsulfanyl-2-methyl-phenoxy)-2-methyl-propionic acid ethyl ester (example 142C]) was reacted with 3-chloromethyl-2-cyclopropyl-6-(4-trifluoromethoxy-phenyl)-pyridine (example 143F]) to give the title compound as colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07115611B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-fc52a2398d61453eb9ef62799a22272c |
| Source note | uspto-grants-2006_10 |