Thionyl Chloride → 5-Chloromethyl-4-methoxymethyl-6-methyl-2-(4-trifluoromethyl-phenyl)-pyrimidine

HRID 1242511Notes

Reaction equation

[CH3:1][O:2][CH2:3][C:4]1[C:9]([CH2:10]O)=[C:8]([CH3:12])[N:7]=[C:6]([C:13]2[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:15][CH:14]=2)[N:5]=1.S(Cl)([Cl:25])=O>>[Cl:25][CH2:10][C:9]1[C:4]([CH2:3][O:2][CH3:1])=[N:5][C:6]([C:13]2[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:15][CH:14]=2)=[N:7][C:8]=1[CH3:12]

Participants

Reactant 2

HCID 24386Thionyl Chloride

HCID 21935612HCID 21935612, compound

Product 1

HCID 219357575-Chloromethyl-4-methoxymethyl-6-methyl-2-(4-trifluoromethyl-phenyl)-pyrimidine

Procedure

In analogy to the procedure described in example 113H], [4-methoxymethyl-6-methyl-2-(4-trifluoromethyl-phenyl)-pyrimidin-5-yl]-methanol and thionylchloride gave the title compound as a light red oil.

Sources & evidence

ORD record: ord-6a39d679356b4503b1b278257bca2508
Source dataset: uspto-grants-2006_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07115611B2

Reaction notes

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