Lithium Hydroxide → 2-{4-[2-Cyclopropylmethyl-6-(4-trifluoromethoxy-phenyl)-4-trifluoromethyl-pyridin-3-ylmethoxy]-2-methyl-phenoxy]-2-methyl-propionic acid

Participants

Role	Name	HCID	Charge
Reactant	Lithium Hydroxide	HCID 3939	—
Reactant	2-{4-[2-Cyclopropylmethyl-6-(4-trifluoromethoxy-phenyl)-4-trifluoromethyl-pyridin-3-ylmethoxy]-2-methyl-phenoxy}-2-methyl-propionic acid ethyl ester	HCID 86597823	—
Product	2-{4-[2-Cyclopropylmethyl-6-(4-trifluoromethoxy-phenyl)-4-trifluoromethyl-pyridin-3-ylmethoxy]-2-methyl-phenoxy]-2-methyl-propionic acid	HCID 21935861	—

Reaction Steps

In analogy to the procedure described in example 26C], 2-{4-[2-cyclopropylmethyl-6-(4-trifluoromethoxy-phenyl)-4-trifluoromethyl-pyridin-3-ylmethoxy]-2-methyl-phenoxy}-2-methyl-propionic acid ethyl ester was treated with 1 N aqueous LiOH solution to give the title compound as off-white crystals.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07115611B2
Source dataset	uspto-grants-2006_10
ORD ID	ord-844a6045891b4faabb29bcc54c00786c
Source note	uspto-grants-2006_10