HRID1242528

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID3939

Lithium hydroxide anhydrous

HLiO

结构：CCOC(=O)C(C)(C)Oc1ccc(OCc2c(C(F)(F)F)cc(-c3ccc(OC(F)(F)F)cc3)nc2CC2CC2)cc1C

HCID86597823

未命名化合物

PRODUCTS

生成物

结构：Cc1cc(OCc2c(C(F)(F)F)cc(-c3ccc(OC(F)(F)F)cc3)nc2CC2CC2)ccc1OC(C)(C)C(=O)O

HCID21935861

未命名化合物

PROCEDURE

实验过程

In analogy to the procedure described in example 26C], 2-{4-[2-cyclopropylmethyl-6-(4-trifluoromethoxy-phenyl)-4-trifluoromethyl-pyridin-3-ylmethoxy]-2-methyl-phenoxy}-2-methyl-propionic acid ethyl ester was treated with 1 N aqueous LiOH solution to give the title compound as off-white crystals.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-844a6045891b4faabb29bcc54c00786c
来源数据集: uspto-grants-2006_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07115611B2
来源说明: uspto-grants-2006_10

反应 SMILES

C([O:3][C:4](=[O:43])[C:5]([O:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:16][C:17]2[C:18]([CH2:38][CH:39]3[CH2:41][CH2:40]3)=[N:19][C:20]([C:27]3[CH:32]=[CH:31][C:30]([O:33][C:34]([F:37])([F:36])[F:35])=[CH:29][CH:28]=3)=[CH:21][C:22]=2[C:23]([F:26])([F:25])[F:24])=[CH:11][C:10]=1[CH3:42])([CH3:7])[CH3:6])C.[Li+].[OH-]>>[CH:39]1([CH2:38][C:18]2[C:17]([CH2:16][O:15][C:12]3[CH:13]=[CH:14][C:9]([O:8][C:5]([CH3:6])([CH3:7])[C:4]([OH:43])=[O:3])=[C:10]([CH3:42])[CH:11]=3)=[C:22]([C:23]([F:26])([F:24])[F:25])[CH:21]=[C:20]([C:27]3[CH:32]=[CH:31][C:30]([O:33][C:34]([F:37])([F:35])[F:36])=[CH:29][CH:28]=3)[N:19]=2)[CH2:41][CH2:40]1