(2S,4EZ)-1-([1,1'-biphenyl]-4-ylcarbonyl)-N'-hydroxy-4-(methoxyimino)-2-pyrrolidinecarboximidamide → HCID 178502619, compound

HRID 1242580Notes

Reaction equation

HRID 1242580 reaction equation
[C:1]1([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH:6]=[CH:5][C:4]([C:7]([N:9]2[CH2:13][C:12](=[N:14][O:15][CH3:16])[CH2:11][C@H:10]2[C:17](=[N:19][OH:20])[NH2:18])=[O:8])=[CH:3][CH:2]=1.[OH:27][C:28]1[CH:36]=[CH:35][C:31]([C:32](O)=O)=[CH:30][N:29]=1>>[CH3:16][O:15][N:14]=[C:12]1[CH2:11][C@@H:10]([C:17]2[N:18]=[C:32]([C:31]3[CH:30]=[N:29][C:28]([OH:27])=[CH:36][CH:35]=3)[O:20][N:19]=2)[N:9]([C:7]([C:4]2[CH:3]=[CH:2][C:1]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)=[CH:6][CH:5]=2)=[O:8])[CH2:13]1

Participants

3

Reactant 2

HCID 90995821(2S,4EZ)-1-([1,1'-biphenyl]-4-ylcarbonyl)-N'-hydroxy-4-(methoxyimino)-2-pyrrolidinecarboximidamide2×HCID 178418479HCID 178418479, compound

Product 1

HCID 178502619HCID 178502619, compoundYield 50%

Procedure

Following the general method as outlined in Example 15, starting from (2S,4EZ)-1-([1,1′-biphenyl]-4-ylcarbonyl)-N′-hydroxy-4-(methoxyimino)-2-pyrrolidinecarboximidamide (Intermediate 8) and 6-hydroxynicotinic-acid, the title compound was obtained in 50% yield (90% purity by HPLC).

Sources & evidence

ORD record
ord-aef3e38f9deb4b498faaec26ed1dd904
Source dataset
uspto-grants-2006_10
Patent number
US07115639B2

Reaction notes

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