Hydrochloric Acid → 4-(p-Fluorophenyl)butyric acid

HRID 1242685Notes

Reaction equation

HRID 1242685 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][C:11]([O:13]C)=[O:12])=[CH:4][CH:3]=1.[OH-].[Na+].Cl>O>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH2:9][CH2:10][C:11]([OH:13])=[O:12])=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 140723Methyl 4-(4-fluorophenyl)butanoate

Product 1

HCID 685244-(p-Fluorophenyl)butyric acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

0.076 mol of the compound obtained in Step C is introduced in a 500 ml round-bottomed flask, and then 250 ml of water and 0.152 mol of NaOH are added. The reaction mixture is stirred for 12 hours at ambient temperature. The reaction mixture is then acidified with 3M HCl and is extracted twice with ethyl ether. The organic phase is dried over MgSO4 and evaporated under reduced pressure to obtain the title product in the form of a white solid.

Workup

  1. extractionis extracted twice with ethyl ether
  2. dry with materialThe organic phase is dried over MgSO4
  3. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-9e5c8a7aa68e4b108d0fcf5f4be8f3e4
Source dataset
uspto-grants-2006_10
Patent number
US07115752B2

Reaction notes

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