Thionyl Chloride → HCID 21917244, compound

HRID 1242692Notes

Reaction equation

HRID 1242692 reaction equation
[F:1][C:2]([F:33])([F:32])[C:3]1[CH:4]=[C:5]([CH:29]=[CH:30][CH:31]=1)[C:6]([NH:8][CH2:9][CH2:10][C:11]1[CH:12]=[CH:13][CH:14]=[C:15]2[C:20]=1[CH:19]=[C:18]([S:21]([CH2:24][CH2:25][C:26](O)=[O:27])(=[O:23])=[O:22])[CH:17]=[CH:16]2)=[O:7].S(Cl)([Cl:36])=O>>[F:1][C:2]([F:33])([F:32])[C:3]1[CH:4]=[C:5]([CH:29]=[CH:30][CH:31]=1)[C:6]([NH:8][CH2:9][CH2:10][C:11]1[CH:12]=[CH:13][CH:14]=[C:15]2[C:20]=1[CH:19]=[C:18]([S:21]([CH2:24][CH2:25][C:26]([Cl:36])=[O:27])(=[O:23])=[O:22])[CH:17]=[CH:16]2)=[O:7]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 21917012HCID 21917012, compound

Product 1

HCID 21917244HCID 21917244, compound

Conditions

Temperature
60 °C

Procedure

The product obtained in Step B (3 mmol), dissolved in thionyl chloride, is stirred at 60° C. under a current of nitrogen for one hour. The thionyl chloride is evaporated off under reduced pressure and the residue is dried with the aid of a vane pump to yield the title product.

Workup

  1. customThe thionyl chloride is evaporated off under reduced pressure
  2. customthe residue is dried with the aid of a vane pump

Sources & evidence

ORD record
ord-d6713289d7784bf3926cf52e2160513a
Source dataset
uspto-grants-2006_10
Patent number
US07115752B2

Reaction notes

Loading…