Thionyl Chloride → 3-[Methyl-(8-{2-[(2-phenylacetyl)amino]ethyl}-2-naphthyl)amino]propanoyl Chloride

HRID 1242698Notes

Reaction equation

HRID 1242698 reaction equation
[CH3:1][N:2]([C:8]1[CH:17]=[CH:16][C:15]2[C:10](=[C:11]([CH2:18][CH2:19][NH:20][C:21](=[O:29])[CH2:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH:12]=[CH:13][CH:14]=2)[CH:9]=1)[CH2:3][CH2:4][C:5](O)=[O:6].S(Cl)([Cl:32])=O>>[CH3:1][N:2]([C:8]1[CH:17]=[CH:16][C:15]2[C:10](=[C:11]([CH2:18][CH2:19][NH:20][C:21](=[O:29])[CH2:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH:12]=[CH:13][CH:14]=2)[CH:9]=1)[CH2:3][CH2:4][C:5]([Cl:32])=[O:6]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 219171333-[Methyl(8-{2-[(2-phenylacetyl)amino]ethyl}-2-naphthyl)amino]propanoic Acid

Product 1

HCID 219168293-[Methyl-(8-{2-[(2-phenylacetyl)amino]ethyl}-2-naphthyl)amino]propanoyl Chloride

Conditions

Temperature
60 °C

Procedure

The product obtained in Step B (3 mmol), dissolved in thionyl chloride, is stirred at 60° C. under a stream of nitrogen for one hour. The thionyl chloride is evaporated off under reduced pressure and the residue is dried using a vane pump to yield the title product.

Workup

  1. customThe thionyl chloride is evaporated off under reduced pressure
  2. customthe residue is dried

Sources & evidence

ORD record
ord-9c0dd8f939c4464ba68ebaf844f0053a
Source dataset
uspto-grants-2006_10
Patent number
US07115752B2

Reaction notes

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