Hydrochloric Acid → HCID 9881712, compound

HRID 1242703Notes

Reaction equation

HRID 1242703 reaction equation
Cl.[CH3:2][S:3][C:4]1[CH:13]=[C:12]2[C:7]([CH2:8][CH2:9][CH2:10][CH:11]2[CH2:14][CH2:15][NH2:16])=[CH:6][CH:5]=1.[C:17](OC(=O)C)(=[O:19])[CH3:18].Cl>N1C=CC=CC=1>[CH3:2][S:3][C:4]1[CH:13]=[C:12]2[C:7]([CH2:8][CH2:9][CH2:10][CH:11]2[CH2:14][CH2:15][NH:16][C:17](=[O:19])[CH3:18])=[CH:6][CH:5]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 7918Acetic AnhydrideHCID 21916681HCID 21916681, compound

Product 1

HCID 9881712HCID 9881712, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

In a 50 ml round-bottomed flask, 0.0025 mol of the compound obtained in Step E is dissolved in 5 ml of pyridine. The solution is cooled with the aid of an ice bath and 5 ml of acetic anhydride are added dropwise. Stirring is carried out for 5 hours at ambient temperature. The reaction mixture is poured into aqueous 3M hydrochloric acid solution and is then extracted with ethyl ether. The organic phase is washed with aqueous 10% potassium carbonate solution and then with water, is dried over magnesium sulphate and is evaporated under reduced pressure. The residue obtained is recrystallised.

Workup

  1. temperatureThe solution is cooled with the aid of an ice bath
  2. extractionis then extracted with ethyl ether
  3. washThe organic phase is washed with aqueous 10% potassium carbonate solution
  4. dry with materialwith water, is dried over magnesium sulphate
  5. customis evaporated under reduced pressure
  6. customThe residue obtained
  7. customis recrystallised

Sources & evidence

ORD record
ord-5fa5afeacef64bcaae89c77f53d458ae
Source dataset
uspto-grants-2006_10
Patent number
US07115752B2

Reaction notes

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