tert-Butyl piperazine-1-carboxylate → tert-Butyl 4-(7H-purin-6-yl)piperazine-1-carboxylate

HRID 1242790Notes

Reaction equation

HRID 1242790 reaction equation
[C:1]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].Cl[C:15]1[N:23]=[CH:22][N:21]=[C:20]2[C:16]=1[NH:17][CH:18]=[N:19]2>>[N:23]1[C:15]([N:11]2[CH2:10][CH2:9][N:8]([C:1]([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2])[CH2:13][CH2:12]2)=[C:16]2[C:20]([N:19]=[CH:18][NH:17]2)=[N:21][CH:22]=1

Participants

3

Reactant 2

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 53592776-Chloropurine

Product 1

HCID 6625649tert-Butyl 4-(7H-purin-6-yl)piperazine-1-carboxylateYield 92%

Procedure

Step 1: Example 136 was prepared by reacting BOC-piperazine with 6-chloropurine according to Example 1. Yield=92%, ES-MS: (M+H)+ 305.

Workup

  1. customStep 1: Example 136 was prepared

Sources & evidence

ORD record
ord-30adf5b66d3a4b4db61ab7e6ec93024e
Source dataset
uspto-grants-2006_10
Patent number
US07115741B2

Reaction notes

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