Tert-Butyl 4-[6-ethyl-2-(methylethyl)thiopheno[3,2-e]pyrimidin-4-yl]piperazinecarboxylate → 1-{4-[6-Ethyl-2-(methylethyl)thiopheno[3,2-e]pyrimidin-4-yl]piperazinyl}-2-phenylethan-1-one

HRID 1242795Notes

Reaction equation

HRID 1242795 reaction equation
C(N1CCN([NH:14][C:15](=[O:23])[CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)CC1)(OC(C)(C)C)=O.[CH2:24]([C:26]1[S:34][C:33]2[N:32]=[C:31]([CH:35]([CH3:37])[CH3:36])[N:30]=[C:29]([N:38]3[CH2:43][CH2:42]N(C(OC(C)(C)C)=O)[CH2:40][CH2:39]3)[C:28]=2[CH:27]=1)[CH3:25]>>[CH2:24]([C:26]1[S:34][C:33]2[N:32]=[C:31]([CH:35]([CH3:37])[CH3:36])[N:30]=[C:29]([N:38]3[CH2:43][CH2:42][N:14]([C:15](=[O:23])[CH2:16][C:17]4[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=4)[CH2:40][CH2:39]3)[C:28]=2[CH:27]=1)[CH3:25]

Participants

3

Reactant 2

HCID 21062815Tert-Butyl 4-[6-ethyl-2-(methylethyl)thiopheno[3,2-e]pyrimidin-4-yl]piperazinecarboxylateHCID 21939585HCID 21939585, compound

Product 1

HCID 210626151-{4-[6-Ethyl-2-(methylethyl)thiopheno[3,2-e]pyrimidin-4-yl]piperazinyl}-2-phenylethan-1-oneYield 21%

Procedure

Phenylacetamidopiperazine hydrochloride (Example 141) was reacted 2-isopropyl-4-chloro-6-ethylthienopyrimidine (Example 162) according to Example 87. Yield=21%, ES-MS: (M+H)+ 409.

Sources & evidence

ORD record
ord-e4709e3cf2564b47bdea5b61bfb8896b
Source dataset
uspto-grants-2006_10
Patent number
US07115741B2

Reaction notes

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