Water → HCID 21939504, compound

Participants

Reaction Steps

2-Bromobenzenesulfonyl chloride (20 g) was dissolved in dichloromethane (100 mL) and cooled to 0° C. tert-Butylamine (8.2 mL) was added followed by triethylamine (16 mL). The reaction was stirred at room temperature until determined complete by analytical HPLC analysis. Water (100 mL) was added and the layers were separated. The aqueous layer was washed with dichloromethane (50 mL) and the combined organic layers were washed with brine (100 mL). Concentration of the organic phase gave 2-bromobenzene-tert-butylsulfonamide (20 g).

Provenance & Evidence