Water → HCID 21939504, compound

HRID 1242803Notes

Reaction equation

HRID 1242803 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8](Cl)(=[O:10])=[O:9].[C:12](N)([CH3:15])([CH3:14])[CH3:13].C([N:19](CC)CC)C.O>ClCCl>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:12]([S:8]([NH2:19])(=[O:10])=[O:9])([CH3:15])([CH3:14])[CH3:13]

Participants

6

Reactant 4

HCID 962WaterHCID 6385Tert-ButylamineHCID 8471TriethylamineHCID 5204032-Bromobenzenesulfonyl chloride

Product 1

HCID 21939504HCID 21939504, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2-Bromobenzenesulfonyl chloride (20 g) was dissolved in dichloromethane (100 mL) and cooled to 0° C. tert-Butylamine (8.2 mL) was added followed by triethylamine (16 mL). The reaction was stirred at room temperature until determined complete by analytical HPLC analysis. Water (100 mL) was added and the layers were separated. The aqueous layer was washed with dichloromethane (50 mL) and the combined organic layers were washed with brine (100 mL). Concentration of the organic phase gave 2-bromobenzene-tert-butylsulfonamide (20 g).

Workup

  1. additionwas added
  2. customthe layers were separated
  3. washThe aqueous layer was washed with dichloromethane (50 mL)
  4. washthe combined organic layers were washed with brine (100 mL)

Sources & evidence

ORD record
ord-2ae31527152849b29fb7e70538e017f7
Source dataset
uspto-grants-2006_10
Patent number
US07115741B2

Reaction notes

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