Sodium Hydroxide → HCID 21939605, compound

HRID 1242805Notes

Reaction equation

HRID 1242805 reaction equation
C([O:3][C:4]([C:6]1[N:7]=[C:8]([N:17]2[CH2:22][CH2:21][N:20]([C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24])[CH2:19][CH2:18]2)[C:9]2[CH:14]=[C:13]([CH2:15][CH3:16])[S:12][C:10]=2[N:11]=1)=[O:5])C.[OH-].[Na+]>CO>[C:26]([O:25][C:23]([N:20]1[CH2:19][CH2:18][N:17]([C:8]2[C:9]3[CH:14]=[C:13]([CH2:15][CH3:16])[S:12][C:10]=3[N:11]=[C:6]([C:4]([OH:5])=[O:3])[N:7]=2)[CH2:22][CH2:21]1)=[O:24])([CH3:29])([CH3:28])[CH3:27]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 69589249HCID 69589249, compound

Product 1

HCID 21939605HCID 21939605, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

4-(4-tert-Butoxycarbonyl-piperazin-1-yl)-6-ethyl-thieno[2,3-d]pyrimidine-2-carboxylic acid ethyl ester (118.9 mg) was dissolved in methanol (0.42 mL) and NaOH (2 M in water, 0.42 mL) was added. The reaction was stirred at room temperature for 3 hours after which, it was neutralized with DOWEX acid ion exchange resin. The mixture was filtered and the filtrate was concentrated to dryness giving the desired product. Yield=100%, ES-MS: (M+H)+ 393.

Workup

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate was concentrated to dryness

Sources & evidence

ORD record
ord-c60a54fd0b5d4795a26a37bfa5891468
Source dataset
uspto-grants-2006_10
Patent number
US07115741B2

Reaction notes

Loading…