Sodium Hydroxide → HCID 21939605, compound

Participants

Reaction Steps

4-(4-tert-Butoxycarbonyl-piperazin-1-yl)-6-ethyl-thieno[2,3-d]pyrimidine-2-carboxylic acid ethyl ester (118.9 mg) was dissolved in methanol (0.42 mL) and NaOH (2 M in water, 0.42 mL) was added. The reaction was stirred at room temperature for 3 hours after which, it was neutralized with DOWEX acid ion exchange resin. The mixture was filtered and the filtrate was concentrated to dryness giving the desired product. Yield=100%, ES-MS: (M+H)+ 393.

Provenance & Evidence