Hydrochloric Acid → HCID 21939399, compound

Participants

Reaction Steps

2-[4-(6-Ethyl-thieno[2,3-d]pyrimidin-4-yl)-piperazine-1-carbonyl]-piperidine-1-carboxylic acid tert-butyl ester (276.1 mg) was dissolved in methanol (1.00 mL) and HCl (4 M in dioxane, 1.00 mL) was added. After stirring at room temperature for 1.5 hours, the solvents were removed and the residue was desalted with MP-carbonate resin in methanol giving the desired free amine. Yield=100%, ES-MS: (M+H)+ 360

Provenance & Evidence