Hydrochloric Acid → HCID 21939399, compound

HRID 1242808Notes

Reaction equation

HRID 1242808 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH:9]1[C:14]([N:16]1[CH2:21][CH2:20][N:19]([C:22]2[C:23]3[CH:30]=[C:29]([CH2:31][CH3:32])[S:28][C:24]=3[N:25]=[CH:26][N:27]=2)[CH2:18][CH2:17]1)=[O:15])=O)(C)(C)C.Cl>CO>[CH2:31]([C:29]1[S:28][C:24]2[N:25]=[CH:26][N:27]=[C:22]([N:19]3[CH2:20][CH2:21][N:16]([C:14]([CH:9]4[CH2:10][CH2:11][CH2:12][CH2:13][NH:8]4)=[O:15])[CH2:17][CH2:18]3)[C:23]=2[CH:30]=1)[CH3:32]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21062828HCID 21062828, compound

Product 1

HCID 21939399HCID 21939399, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2-[4-(6-Ethyl-thieno[2,3-d]pyrimidin-4-yl)-piperazine-1-carbonyl]-piperidine-1-carboxylic acid tert-butyl ester (276.1 mg) was dissolved in methanol (1.00 mL) and HCl (4 M in dioxane, 1.00 mL) was added. After stirring at room temperature for 1.5 hours, the solvents were removed and the residue was desalted with MP-carbonate resin in methanol giving the desired free amine. Yield=100%, ES-MS: (M+H)+ 360

Workup

  1. customthe solvents were removed

Sources & evidence

ORD record
ord-23aaa422ba3241a985abf889b34614b0
Source dataset
uspto-grants-2006_10
Patent number
US07115741B2

Reaction notes

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