Piperidine → HCID 69497341, compound

HRID 1242901Notes

Reaction equation

HRID 1242901 reaction equation
[C:1]([NH:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[C:11](=[O:15])[C:10](=[CH:16][N:17]([CH3:19])[CH3:18])[CH2:9][CH2:8]2)(=[O:3])[CH3:2].N1CC[CH2:23][CH2:22][CH2:21]1>>[C:1]([NH:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[C:11](=[O:15])[C:10](=[CH:16][N:17]1[CH2:18][CH2:23][CH2:22][CH2:21][CH2:19]1)[CH2:9][CH2:8]2)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 8082PiperidineHCID 57373319HCID 57373319, compound

Product 1

HCID 69497341HCID 69497341, compound

Procedure

A mixture of 6-acetamido-2-(N,N-dimethylaminomethylidene)-1-tetralone (11 g) obtained in Example 41-1) and piperidine (100 ml) was refluxed with heating for 24 hours. After excess piperidine was distilled out under reduced pressure, the resulting residue was crystallized using tetrahydrofuran-isopropyl ether to give 6-acetamido-2-(1-piperidinylmethylidene)-1-tetralone (7 g) as a light yellow powder.

Workup

  1. temperaturewas refluxed
  2. temperaturewith heating for 24 hours
  3. distillationAfter excess piperidine was distilled out under reduced pressure
  4. customthe resulting residue was crystallized

Sources & evidence

ORD record
ord-0d72a695ffdf4f63b078eb674369d302
Source dataset
uspto-grants-2006_10
Patent number
US07115750B1

Reaction notes

Loading…